Ítem


Increase in c-Fos and Arc protein in retrosplenial cortex after memory-improving lateral hypothalamic electrical stimulation treatment

Post-training Intracranial self-stimulation (ICSS) of the lateral hypothalamus (LH), a kind of rewarding deep-brain stimulation, potentiates learning and memory and increases c-Fos protein expression in specific memory-related brain regions. In a previous study, Aldavert-Vera et al. (2013) reported that post-acquisition LH-ICSS improved 48. h retention of a delay two-way active avoidance conditioning (TWAA) and induced c-Fos expression increase in CA3 at 90. min after administration. Nevertheless, this c-Fos induction was only observed after the acquisition session and not after the retention test at 48. h, when the ICSS improving effect was observed on memory. This current study aims to examine the hypothesis that post-training ICSS treatment may stimulate c-Fos expression at the time of the TWAA retention test in retrosplenial cortex (RSC), a hippocampus-related brain region more closely related with long-lasting memory storage. Effects of ICSS on Arc protein, a marker of memory-associated synaptic plasticity, were also measured by immunohistochemistry in granular and agranular RSC. The most innovative results are that the ICSS treatment potentiates the c-Fos induction across TWAA conditions (no conditioning, acquisition and retention), specifically in layer V of the granular RSC, along with increases of Arc protein levels in the granular but not in agranular areas of RSC ipsilaterally few hours after ICSS. This leads us to suggest that plasticity-related protein activation in the granular RSC could be involved in the positive modulatory effects of ICSS on TWAA memory consolidation, opening a new approach for future research in ICSS memory facilitation

We gratefully acknowledge grant support from the Spanish Ministerio de Ciencia e Innovación (I+D project PSI2013-41018-P)

© Neurobiology of Learning and Memory, 2016, vol. 128, p. 117-124

Elsevier

Autor: Kádár García, Elisabeth
Vico-Varela, Eva
Aldavert-Vera, Laura
Huguet i Blanco, Gemma
Morgado-Bernal, Ignacio
Segura-Torres, Pilar
Data: 2016
Resum: Post-training Intracranial self-stimulation (ICSS) of the lateral hypothalamus (LH), a kind of rewarding deep-brain stimulation, potentiates learning and memory and increases c-Fos protein expression in specific memory-related brain regions. In a previous study, Aldavert-Vera et al. (2013) reported that post-acquisition LH-ICSS improved 48. h retention of a delay two-way active avoidance conditioning (TWAA) and induced c-Fos expression increase in CA3 at 90. min after administration. Nevertheless, this c-Fos induction was only observed after the acquisition session and not after the retention test at 48. h, when the ICSS improving effect was observed on memory. This current study aims to examine the hypothesis that post-training ICSS treatment may stimulate c-Fos expression at the time of the TWAA retention test in retrosplenial cortex (RSC), a hippocampus-related brain region more closely related with long-lasting memory storage. Effects of ICSS on Arc protein, a marker of memory-associated synaptic plasticity, were also measured by immunohistochemistry in granular and agranular RSC. The most innovative results are that the ICSS treatment potentiates the c-Fos induction across TWAA conditions (no conditioning, acquisition and retention), specifically in layer V of the granular RSC, along with increases of Arc protein levels in the granular but not in agranular areas of RSC ipsilaterally few hours after ICSS. This leads us to suggest that plasticity-related protein activation in the granular RSC could be involved in the positive modulatory effects of ICSS on TWAA memory consolidation, opening a new approach for future research in ICSS memory facilitation
We gratefully acknowledge grant support from the Spanish Ministerio de Ciencia e Innovación (I+D project PSI2013-41018-P)
Format: application/pdf
ISSN: 1074-7427
Accés al document: http://hdl.handle.net/10256/12360
Llenguatge: eng
Editor: Elsevier
Col·lecció: MINECO/PN 2014-2016/PSI2013-41018-P
Reproducció digital del document publicat a: http://dx.doi.org/10.1016/j.nlm.2015.12.012
Articles publicats (D-B)
És part de: © Neurobiology of Learning and Memory, 2016, vol. 128, p. 117-124
Drets: Tots els drets reservats
Matèria: Memòria -- Efecte dels medicaments
Memory -- Effect of drugs on
Títol: Increase in c-Fos and Arc protein in retrosplenial cortex after memory-improving lateral hypothalamic electrical stimulation treatment
Tipus: info:eu-repo/semantics/article
Repositori: DUGiDocs

Matèries

Autors