Ítem
| Ministerio de Economía y Competitividad (Espanya) | |
|
Planas Fàbrega, Oriol
Whiteoak, Christopher J. Company Casadevall, Anna Ribas Salamaña, Xavi |
|
| 2015 | |
|
The use of cobalt as catalyst in direct C-H activation protocols as a replacement for more expensive second row transition metals is currently attracting significant attention. Herein we disclose a facile cobalt-catalyzed C-H functionalization route towards sultam motifs through annulation of easily prepared aryl sulfonamides and alkynes using 8-aminoquinoline as a directing group. The reaction shows broad substrate scope with products obtained in a highly regioselective manner in good to excellent isolated yields. Mechanistic insights suggest the formation of a Co(III)-aryl key species via a rate-determining arene C-H activation during the annulation reaction We acknowledge financial support from the ERC for the Starting Grant Project ERC-2011-StG-277801 to X.R. and MINECO of Spain for CTQ2013-43012-P to X.R. and A.C, and a RyC contract to A.C. |
|
| application/pdf | |
| http://hdl.handle.net/10256/12495 | |
| eng | |
| Wiley | |
|
info:eu-repo/semantics/altIdentifier/doi/10.1002/adsc.201500690 info:eu-repo/semantics/altIdentifier/issn/1615-4150 info:eu-repo/semantics/altIdentifier/eissn/1615-4169 info:eu-repo/grantAgreement/MINECO//CTQ2013-43012-P/ES/INVESTIGACIONES MECANISTICAS PARA SINTESIS ORGANICA SOSTENIBLE VIA ACTIVACION DE PEQUEÑAS MOLECULAS GASEOSAS Y DE ENLACES C-H CON METALES DE LA PRIMERA SERIE DE TRANSICION/ info:eu-repo/grantAgreement/EC/FP7/277801/EU/Sustainable C-X and C-H Functionalization Catalyzed by Copper(III) Species/SUSCATCU3 |
|
| Tots els drets reservats | |
|
Alquins
Alkynes Activació (Química) Activation (Chemistry) Reaccions químiques regioselectives Chemical reactions Sulfonamides Sulfonamides |
|
| Regioselective Access to Sultam Motifs through Cobalt-Catalyzed Annulation of Aryl Sulfonamides and Alkynes using an 8-Aminoquinoline Directing Group | |
| info:eu-repo/semantics/article | |
| DUGiDocs |
