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Concentration and risk of pharmaceuticals in freshwater systems are related to the population density and the livestock units in Iberian Rivers

Considerable amounts of pharmaceuticals are used in human and veterinary medicine, which are not efficiently removed during wastewater and slurries treatment and subsequently entering continuously into freshwater systems. The intrinsic biological activity of these non-regulated pollutants turns their presence in the aquatic environment into an ecological matter of concern. We present the first quantitative study relating the presence of pharmaceuticals and their predicted ecotoxicological effects with human population and livestock units. Four representative Iberian River basins (Spain) were studied: Llobregat, Ebro, Júcar and Guadalquivir. The levels of pharmaceuticals were determined in surface water and sediment samples collected from 77 locations along their stream networks. Predicted total toxic units to algae, Daphnia and fish were estimated for pharmaceuticals detected in surface waters. The use of chemometrics enabled the study of pharmaceuticals for: their spatial distribution along the rivers in two consecutive years; their potential ecotoxicological risk to aquatic organisms; and the relationships among their occurrence and predicted ecotoxicity with human population and animal farming pressure. The Llobregat and the Ebro River basins were characterized as the most polluted and at highest ecotoxicological risk, followed by Júcar and Guadalquivir. No significant acute risks of pharmaceuticals to aquatic organisms were observed. However potential chronic ecotoxicological effects on algae could be expected at two hot spots of pharmaceuticals pollution identified in the Llobregat and Ebro basins. Analgesics/antiinflammatories, antibiotics and diuretics were the most relevant therapeutic groups across the four river basins. Among them, hydrochlorothiazide and gemfibrozil, as well as azithromycin and ibuprofen were widely spread and concentrated pharmaceuticals in surface waters and sediments, respectively. Regarding their predicted ecotoxicity, sertraline, gemfibrozil and loratidine were identified as the more concerning compounds. Significantly positive relationships were found among levels of pharmaceuticals and toxic units and population density and livestock units in both surface water and sediment matrices

Authors would like to thank the Spanish Ministry of Economy and Competitiveness for its financial support through the projects SCARCE (Consolider-Ingenio 2010 CSD2009-00065). This work has been supported by the European Union Seventh Framework Programme Funding under Grant agreement no. 603629-ENV-2013-6.2.1 Globaqua and by the Generalitat de Catalunya (Consolidated Research Groups “2014 SGR 418 — Water and Soil Quality Unit” and 2014 SGR 291-ICRA

Science of the Total Environment, 2016, vol. 540, p. 267-277

Elsevier

Author: Osorio, Victoria
Larrañaga Arrizabalaga, Aitor
Aceña, Jaume
Pérez, Sandra
Barceló i Cullerés, Damià
Date: 2016 January 1
Abstract: Considerable amounts of pharmaceuticals are used in human and veterinary medicine, which are not efficiently removed during wastewater and slurries treatment and subsequently entering continuously into freshwater systems. The intrinsic biological activity of these non-regulated pollutants turns their presence in the aquatic environment into an ecological matter of concern. We present the first quantitative study relating the presence of pharmaceuticals and their predicted ecotoxicological effects with human population and livestock units. Four representative Iberian River basins (Spain) were studied: Llobregat, Ebro, Júcar and Guadalquivir. The levels of pharmaceuticals were determined in surface water and sediment samples collected from 77 locations along their stream networks. Predicted total toxic units to algae, Daphnia and fish were estimated for pharmaceuticals detected in surface waters. The use of chemometrics enabled the study of pharmaceuticals for: their spatial distribution along the rivers in two consecutive years; their potential ecotoxicological risk to aquatic organisms; and the relationships among their occurrence and predicted ecotoxicity with human population and animal farming pressure. The Llobregat and the Ebro River basins were characterized as the most polluted and at highest ecotoxicological risk, followed by Júcar and Guadalquivir. No significant acute risks of pharmaceuticals to aquatic organisms were observed. However potential chronic ecotoxicological effects on algae could be expected at two hot spots of pharmaceuticals pollution identified in the Llobregat and Ebro basins. Analgesics/antiinflammatories, antibiotics and diuretics were the most relevant therapeutic groups across the four river basins. Among them, hydrochlorothiazide and gemfibrozil, as well as azithromycin and ibuprofen were widely spread and concentrated pharmaceuticals in surface waters and sediments, respectively. Regarding their predicted ecotoxicity, sertraline, gemfibrozil and loratidine were identified as the more concerning compounds. Significantly positive relationships were found among levels of pharmaceuticals and toxic units and population density and livestock units in both surface water and sediment matrices
Authors would like to thank the Spanish Ministry of Economy and Competitiveness for its financial support through the projects SCARCE (Consolider-Ingenio 2010 CSD2009-00065). This work has been supported by the European Union Seventh Framework Programme Funding under Grant agreement no. 603629-ENV-2013-6.2.1 Globaqua and by the Generalitat de Catalunya (Consolidated Research Groups “2014 SGR 418 — Water and Soil Quality Unit” and 2014 SGR 291-ICRA
Format: application/pdf
ISSN: 0048-9697
Document access: http://hdl.handle.net/10256/12597
Language: eng
Publisher: Elsevier
Collection: MICINN/PN 2009-2014/CSD2009-00065
Reproducció digital del document publicat a: http://dx.doi.org/10.1016/j.scitotenv.2015.06.143
Articles publicats (ICRA)
info:eu-repo/grantAgreement/EC/FP7/603629
Is part of: Science of the Total Environment, 2016, vol. 540, p. 267-277
Rights: Attribution-NonCommercial-NoDerivs 3.0 Spain
Rights URI: http://creativecommons.org/licenses/by-nc-nd/3.0/es/
Subject: Toxicologia ambiental
Environmental toxicology
Medicaments -- Aspectes ambientals
Drugs -- Environmental aspects
Aigua -- Contaminació
Water -- Pollution
Title: Concentration and risk of pharmaceuticals in freshwater systems are related to the population density and the livestock units in Iberian Rivers
Type: info:eu-repo/semantics/article
Repository: DUGiDocs

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